Palestino secured a memorable 2-1 away victory over Universidad de Chile in a Chilean derby in the CONMEBOL Copa Sudamericana on March 5, 2026. The result was a major upset, as Palestino overcame their more-fancied rivals with a display of tactical discipline and clinical finishing. Universidad de Chile started brightly and took the lead with a well-worked team goal. However, Palestino equalized against the run of play just before halftime from a set-piece. The second half saw a shift in momentum, and Palestino grabbed a shock winner midway through the period with a powerful shot from distance. La U threw everything forward in search of an equalizer, but Palestino's defense held firm under immense pressure. This victory gave Palestino a dream start to their group stage campaign and bragging rights in Santiago, while leaving Universidad de Chile with a surprising deficit to overcome.