CA Peñarol began their CONMEBOL Copa Libertadores campaign with a comfortable 3-0 away win over San Antonio Bulo Bulo on May 7, 2025. The Uruguayan giants navigated a potentially tricky trip to Bolivia with professionalism, securing a vital three points in Group H. Peñarol took control of the match early, scoring their first goal from a set-piece to settle any nerves. They added two more in the second half as the altitude and conditions began to affect the home side, with their superior technical quality shining through. San Antonio Bulo Bulo, making their debut in the competition, fought hard but were ultimately outclassed by the experience of Peñarol. The match was played at a frenetic pace initially, but Peñarol's game management was exemplary. This win positioned Peñarol favorably in a competitive group. The Peñarol manager praised his team's adaptability, while the San Antonio coach highlighted the valuable experience gained for his players.