América de Cali Women began their Liga Betplay Femenina campaign with a 2-0 home victory over Fortaleza CEIF FC Women on February 24, 2025. The win at the Estadio Olímpico Pascual Guerrero provided a solid foundation for the season as the hosts controlled the match from the outset. The match process saw América de Cali apply early pressure, breaking the deadlock in the first half before adding a second goal after the interval to seal the points. The key focus point was the team's organized performance and clinical finishing, which contrasted with Fortaleza's struggle to create significant chances. This result immediately placed América de Cali Women in a strong position in the early league table. The Fortaleza coach would have highlighted the need for a sharper response in future matches.