Independiente Santa Fe suffered a 3-0 home defeat to Deportivo Independiente Medellín in the Colombian Copa BetPlay DIMAYOR on October 2, 2025. The match, which kicked off at 09:00, saw the visiting Medellín side put on a clinical display to secure a commanding victory. DIM took control of the match early, scoring crucial away goals that put Santa Fe under immense pressure. The home team struggled to create meaningful chances against a well-organized defense, while Medellín capitalized on their opportunities to seal the win. This result gives Deportivo Independiente Medellín a significant advantage heading into the second leg of the cup tie. For Santa Fe, they face a major challenge to overturn the deficit in the return fixture.