CSD Antofagasta ended Municipal Iquique's Chilean Cup run with a 3-1 victory in the round of 16 on May 12, 2025. The match, starting at 00:30, saw Antofagasta's superior firepower ultimately prove decisive against their regional rivals. Antofagasta took control early, scoring twice in the opening twenty minutes to stun the visitors. Iquique managed to pull a goal back just before halftime from a penalty, setting up a tense second half. However, any hopes of another Iquique comeback were extinguished when Antofagasta restored their two-goal cushion with a well-worked team goal midway through the second period. Iquique pushed forward in search of a lifeline but found the Antofagasta defense in uncompromising form. The result sees CSD Antofagasta progress to the quarter-finals of the Copa Chile, while Municipal Iquique's focus now shifts entirely to their league campaign. The Antofagasta coach was pleased with his team's professional performance, while Iquique's manager acknowledged the quality of the opposition on the night.